Effects of daily multivitamin–multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial

Sidong Li / nature - Nature Medicine, Published online: 09 March 2026; doi:10.1038/s41591-026-04239-3In a prespecified ancillary analysis of the COSMOS randomized trial, supplementation with daily multivitamins, but not with cocoa extract, over the course of 2 years decreased…

AI Summary: A prespecified ancillary analysis of the COSMOS randomized trial found that daily multivitamin–multimineral (with cocoa extract) modestly slowed epigenetic aging clocks over two years. The Nature Medicine report highlights measurable shifts in biomarkers of biological aging, while noting uncertain clinical significance and the need for longer follow-up.