How springing forward to daylight saving time could affect your health
medicalxpress - Most of America "springs forward" Sunday for daylight saving time. Losing that hour of sleep can do more than leave you tired and cranky the next day; it also could harm your health.
AI Summary: The clock change that robs people of an hour of sleep is back, and so are the predictable health hiccups: disrupted circadian rhythm, deeper sleep loss and more migraine flare‑ups. Experts warn even a single lost hour can nudge vulnerable people toward worse sleep, mood and short‑term cardiovascular risk — so yes, your crankiness is data‑backed.
CART19-BE-02 trial: From Bench to Bedside and Beyond – Resonance
oncodaily - ALRCaN presents “CART19-BE-02 trial: From Bench to Bedside and Beyond—Implementing a Hospital-Based CAR T Program and Integrating It into the Spanish NHS” with Dr. Valentín Ortiz-Maldonado. “Dear friends and colleagues, […]
AI Summary: Bereaved relatives delivered searing final testimonies as the Covid inquiry wound up four years of public hearings, recounting loved ones who died alone and demanding answers. Chair Baroness Heather Hallett defended the process and its roughly £200 million price tag as necessary to finish the work, despite public frustration and political scrutiny.
Telehealth growth hasn’t increased rural behavioral healthcare access: Study
Giles Bruce / beckershospitalreview - The rise in telemedicine over the past several years hasn’t translated to more behavioral healthcare access in rural areas, according to a March 5 study in JAMA Network Open. Researchers from Boston-based Harvard Medical School and Providence, R.I.-based …
AI Summary: A new study finds the rapid expansion of telemedicine did not meaningfully improve access to behavioral health services in rural areas. Persistent barriers—workforce shortages, broadband gaps, and reimbursement limits—keep telehealth from being the miracle fix some hoped for. Turns out, high-speed internet isn’t a therapist.
Optum Rx, Caremark making ‘significant progress’ in settlement talks with FTC
Rebecca Pifer Parduhn / healthcaredive - It’s looking increasingly likely that the UnitedHealth and CVS drug middlemen will also make peace with federal regulators, after Cigna agreed to a sweeping settlement in the insulin lawsuit last month.
AI Summary: Federal regulators and two pharmacy benefit managers are reportedly making substantial progress toward resolving an FTC antitrust probe tied to insulin pricing and PBM practices. Negotiations aim to settle allegations without protracted litigation, potentially changing how PBMs operate and how insulin costs are managed for states and patients.
Moderna to Pay Up to $2.25B to Settle Patent Suit Over Covid-19 Vaccine Technology
Frank Vinluan / medcitynews - Under the settlement, Genevant Sciences and Arbutus Biopharma will grant Moderna a non-exclusive license to their lipid nanoparticle technology for mRNA delivery in infectious disease vaccines. If Moderna’s full financial payout to the companies is reache…
AI Summary: Moderna has agreed to settle long-running patent disputes over its COVID-19 vaccine technology for up to $2.25 billion, resolving litigation with several claimants. The deal provides Moderna with broad licensing rights and clears a major legal uncertainty, allowing the company to move forward without another courtroom cliffhanger.
FDA vaccine chief to step down in April
Ella Jeffries / beckershospitalreview - Vinay Prasad, MD, the FDA’s top regulator of vaccines and cell and gene therapies, will step down at the end of April, an agency spokesperson confirmed to Becker’s. Dr. Prasad joined the agency in 2025 on a one-year sabbatical from the University of Calif…
AI Summary: Vinay Prasad, the FDA’s top regulator for vaccines and cell and gene therapies, will step down at the end of April amid mounting criticism over controversial decisions that reportedly overrode agency scientists and spooked stakeholders. His exit follows prolonged internal and external disputes about regulatory judgment and leadership style.
Hospitals urge regulators to halt drugmakers’ expanded 340B data policies
Emily Olsen / healthcaredive - The American Hospital Association argues new policies from Eli Lilly and Novo Nordisk requiring providers to submit more claims data on dispensed 340B drugs is onerous and unlawful.
AI Summary: Hospitals and provider groups are urging federal regulators to halt new drugmaker policies that expand claims-data reporting tied to 340B discounts, calling the requirements unlawful and administratively burdensome. The dispute pits safety-net providers against manufacturers seeking program transparency — a classic tug-of-war with patients’ financial stakes caught in the middle.
GLP‑1 drugs may fight addiction across every major substance, according to a study of 600,000 people
medicalxpress - A patient of mine, a veteran who had tried to quit smoking for over a decade, told me that after he started a GLP-1 drug for his diabetes, he lost interest in cigarettes. He didn't use a patch. He didn't set a quit date. He simply lost interest. It happen…
AI Summary: A large observational analysis suggests GLP‑1 receptor agonists — the headline-grabbing diabetes and weight-loss drugs — are linked to reduced risk of developing and dying from substance use disorders across multiple substances. Researchers urge cautious optimism: signals are intriguing, but causality remains unproven and more controlled trials are needed before rewriting addiction treatment playbooks.
AI blood test finds silent liver disease years before symptoms
sciencedaily - Researchers created an AI-driven liquid biopsy that scans patterns in fragments of DNA circulating in the blood. The system detected early liver fibrosis and cirrhosis—conditions that often go unnoticed until serious damage occurs. By analyzing genome-wid…
AI Summary: Researchers unveiled an AI‑driven liquid biopsy that scans genome‑wide cell‑free DNA fragment patterns to flag liver fibrosis, cirrhosis and chronic liver disease well before symptoms appear. Early results indicate the test can identify disease signals years ahead of clinical diagnosis, offering a shot at much earlier intervention — if practice and payers cooperate.
Groundbreaking new drug shows promise for treating children with a devastating form of epilepsy
livescience - An experimental treatment reduces seizures and other symptoms in children with a type of epilepsy called Dravet syndrome.
AI Summary: An experimental treatment markedly cut seizures and eased symptoms in children with Dravet syndrome, offering families dramatic improvements where few options existed. Early clinical data show promising safety and efficacy signals, but researchers caution larger, longer trials and regulatory review are needed before this becomes a routine option.
Adding Hormone Therapy to PORT Might Not Benefit Patients with Recurrent Prostate Cancer and PSA of 0.5 ng/mL or Less
esmo - Findings from the POSEIDON meta-analysis of the MARCAP consortium
AI Summary: A pooled POSEIDON meta-analysis from the MARCAP consortium found that adding androgen-deprivation therapy to post‑operative radiotherapy for recurrent prostate cancer with PSA ≤0.5 ng/mL does not improve outcomes meaningfully. In short: the extra hormonal punch may not be worth the side effects many patients will endure.
RFK Jr. names 2 new members to CDC vaccine panel
Erica Cerutti / beckershospitalreview - HHS Secretary Robert F. Kennedy Jr. appointed two new members to the CDC’s vaccine advisory committee Feb. 27, ahead of a rescheduled meeting in mid-March where members are expected to review COVID-19 vaccine recommendations. Mr. Kennedy said Sean Downing…
AI Summary: HHS Secretary Robert F. Kennedy Jr. appointed two clinicians to the CDC’s Advisory Committee on Immunization Practices just weeks before a rescheduled session, installing new voting members ahead of vaccine deliberations. The last‑minute nominations aim to ensure the panel is fully staffed for upcoming guidance discussions.
Parents of gravely ill child refused respite care
bbc - Birmingham Children's Trust refused respite help and suggested training grandparents to help.
AI Summary: Parents of a gravely ill child report being refused respite care, leaving caregivers exhausted and without relief while bureaucratic responses pivot to training relatives. The situation exposes gaps in social and health services for high‑need families and the human cost of systems designed for checkboxes, not real lives.
After 4-Week Strike, Kaiser Permanente Workers Score Tentative Win on Staffing & Pay
Katie Adams / medcitynews - About 31,000 Kaiser Permanente workers ended a four-week strike after reaching a tentative agreement that includes measures to address chronic understaffing and wage increases. The full contract has not yet been ratified.The post After 4-Week Strike, Kais…
AI Summary: After a four‑week strike, roughly 31,000 Kaiser Permanente workers reached a tentative agreement that includes commitments on staffing levels and compensation. The deal ends a major labor standoff that had disrupted services and put pressure on management to address long‑standing workforce concerns.
CMS freezes $260M in Medicaid funding to Minnesota, citing fraud concerns
Jakob Emerson / beckershospitalreview - CMS is freezing $259.5 million in federal Medicaid funding to Minnesota, citing unsupported or potentially fraudulent claims in the state’s program. “We have decided to temporarily halt certain amounts of Medicaid funding that are going to the state of Mi…
AI Summary: Officials confirmed avian influenza in elephant seal pups at Año Nuevo State Park, prompting the suspension of seal‑watching tours and an urgent wildlife response. Several pups have died; researchers are testing samples and authorities are warning the public to avoid contact while investigations continue.
Microplastics discovered in prostate tumors
medicalxpress - Small fragments of plastic were found in 9 out of 10 patients with prostate cancer, and in higher levels inside tumors than in nearby noncancerous tissue, a new study finds. The small, single-center study was led by researchers at NYU Langone Health, its …
AI Summary: Researchers report finding microplastic fragments in the vast majority of examined prostate tumor samples, at higher levels than surrounding noncancerous tissue. The study raises uneasy questions about environmental contaminants accumulating in human tissues and their potential interactions with cancer biology, though causation remains unproven and further research is clearly overdue.
Boehringer wins accelerated approval for first-line use of lung cancer drug
Lei Lei Wu / endpoints - The FDA greenlit an expanded label for Boehringer Ingelheim’s lung cancer drug Hernexeos, marking the first use of the Commissioner's National Priority Voucher for a new indication. Boehringer won an accelerated
AI Summary: Regulators accelerated approval of Boehringer Ingelheim’s lung cancer therapy for first‑line use, leveraging a priority review mechanism that sped the timeline. The label expansion places the drug into earlier treatment settings, reflecting promising data and the efficiency (and occasional controversy) of voucher‑assisted regulatory pathways.
Patient dies in MacroGenics' cancer study, FDA puts trial on hold
Max Gelman / endpoints - The FDA has placed a partial clinical hold on MacroGenics’ Phase 2 study in gynecologic cancers after one patient died and three others experienced life-threatening side effects, the company disclosed Tuesday. The patient who died ...
AI Summary: Regulators have imposed a partial hold on a Phase 2 gynecologic cancer trial after multiple serious adverse events, including one patient death and additional safety incidents. The pause mandates review of trial protocols and safety monitoring before enrollment can resume, highlighting the inherent risks when experimental therapies meet human biology.
UHS posts 11.5% operating margin in 2025 as net income jumps 30%
Andrew Cass / beckershospitalreview - King of Prussia, Pa.-based Universal Health Services recorded a net income of $1.5 billion in 2025, up from $1.1 billion in 2024, according to its Feb. 25 financial report. Eight things to know: 1. The for-profit system reported an operating income of $2 …
AI Summary: Universal Health Services reported robust 2025 financial results and outlined an optimistic 2026 outlook, driven by acute and behavioral health operations. Leadership flagged growth targets for admissions and behavioral services even as staffing and regulatory pressures persist — the usual blend of confidence and contingency planning.
Cancer blood test fails to catch disease earlier in major study
medicalxpress - A blood test designed to find cancer early did not work as hoped in a major new study, according to the company that makes it.
AI Summary: A large trial evaluating GRAIL’s multi‑cancer blood screening test failed to meet its primary goal of earlier cancer detection. The disappointing result casts doubt on the test’s clinical utility for population screening, sparks debate over marketing and clinical use, and prompts calls for clearer evidence before widespread adoption.