Zoldonrasib Shows Early Strength in Previously Treated KRAS G12D NSCLC

oncodaily - KRAS G12D has long been one of the most frustrating targets in thoracic oncology. It is biologically important, clearly druggable in theory, and yet patients with KRAS G12D-mutant non-small cell […]

AI Summary: Investigational KRAS(ON) inhibitor zoldonrasib produced effective, durable responses in patients with advanced KRAS G12D–mutated non‑small‑cell lung cancer after prior therapy. Early‑phase data show meaningful tumour shrinkage and a manageable safety profile, offering a targeted option for a mutation long considered untargetable and breathing new life into KRAS drug development.


Experts on site: RAS inhibitors reshape NSCLC treatment landscape

Young Kwang Chae: The Future of RAS Therapy May Be in the Syringe Rather Than the Pill

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Fawzi Abu Rous: Turning KRAS From “Undruggable” to a Targetable Driver in NSCLC

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Ahmet Dirican: What Did Targeting KRAS Teach Us?

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David Hong: The RAS Revolution Is Taking Off in NSCLC

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Ariella Hanker: AACR26 Is “Still” the Year of RAS Inhibitors

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Industry moves: BridgeBio reshuffles as KRAS race heats up

BridgeBio’s oncology spinoff swaps out CEOs as it seeks to accelerate KRAS work

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On the AACR floor: zoldonrasib delivers durable G12D responses

Jonathan W. Riess on Zoldonrasib Effectiveness in Previously Treated KRAS G12D NSCLC – AACR

4 months / oncodaily

KRAS(ON) inhibitor zoldonrasib showed effective, durable responses in patients with advanced G12D-mutated lung cancer

4 months / medicalxpress

Zoldonrasib Shows Early Strength in Previously Treated KRAS G12D NSCLC

4 months / oncodaily

Investigational KRAS(ON) Inhibitor Zoldonrasib Showed Effective and Durable Responses in Patients With Advanced G12D-mutated Lung Cancer

4 months / aacr / Julia DeMalto


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All Other Stories

KRAS G12C Inhibitors In NSCLC: From “Undruggable” To First-Line Contender

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Erasca reports RAS cancer drug data after legal threat from Revolution

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KIRHub Opens A New Repurposing Map For Kinase Inhibitors In Lung Cancer

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Nicholas Hornstein: Anticipating Resistance and Revolution Medicines’ Proactive Strategy for RAS Therapy

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Nicholas Hornstein: Recent Data on RAS Therapies

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