Skin protein K16 found to control inflammation in stressed skin

medicalxpress - Keratin is the fibrous, waterproof protein that builds everything from our hair and nails to a rhino's horn. However, a tiny glitch in it can have problematic outcomes. A new study has found that changes in a keratin gene called KRT16 can lead to a rare c…

AI Summary: Researchers identified keratin 16 (K16) as a molecular brake on skin inflammation: loss of K16 ramps up interferon-driven immune signals, while its presence calms stressed keratinocytes. The discovery points to new targets for inflammatory skin disorders and suggests modulating K16 pathways could yield therapies that actually treat inflammation, not just slap on a cream.

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