Researchers identify immune cell that builds cancer-fighting hubs inside tumors

medicalxpress - Researchers at the Icahn School of Medicine at Mount Sinai have identified the immune cell that acts as the architect and coordinator of powerful immune hubs that form inside tumors and plays a key role in antitumor immunity. This discovery could lead to …

AI Summary: Researchers discovered a subset of dendritic cells that orchestrate formation and maintenance of tertiary lymphoid structures—local immune “hubs”—inside tumours. These niches concentrate and sustain anti-tumour T cells, explaining how some cancers spontaneously marshal immune responses and opening avenues to boost immunotherapy by enhancing or mimicking this dendritic cell-driven architecture.

• Discovery: dendritic cells build tumour immune hubs (3)
• Molecular and systemic regulators of tumour immune hubs (3)
• Therapeutic strategies: boosting T cells and DC vaccines (3)

Discovery: dendritic cells build tumour immune hubs

Molecular and systemic regulators of tumour immune hubs

Therapeutic strategies: boosting T cells and DC vaccines