oncodaily - Dana-Farber Cancer Institute shared a post on LinkedIn: “For years, RAS was considered one of the toughest targets in cancer research. In pancreatic cancer, that challenge is especially urgent. New […]
AI Summary: A targeted RAS inhibitor, daraxonrasib, produced promising clinical activity in patients with NRAS-mutant melanoma, demonstrating tumor responses and a tolerable safety profile in early studies. The data suggest a viable therapeutic avenue for a historically hard-to-treat subset and justify larger trials to confirm benefit — because apparently NRAS wasn’t going to cure itself.
Enhertu (DESTINY‑Lung04) improves PFS in HER2‑mutant lung cancer / 9 days
Engineered bacteria show promise as tumor‑targeting therapy in preclinical studies / 6 wks
Rogaratinib shows activity in SDH‑deficient GIST phase 2 trial / 3 months
Genetic clues explain tagraxofusp resistance in rare leukemia (BPDCN) / 7 wks
Adjuvant selpercatinib sharply cuts recurrence in RET‑fusion lung cancer / 2 months
CRISPR CD33‑deleted allogeneic transplant shows early AML promise / 3 months
Single‑cycle pembrolizumab yields striking responses in dMMR colon cancer / 3 months
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