FOURLIGHT-1: Atirmociclib Reduces Progression Risk After Prior CDK4/6 Inhibition
oncodaily - Selective CDK4 inhibition has produced its first randomized efficacy signal after progression on conventional CDK4/6 inhibitor therapy in hormone receptor-positive, HER2-negative advanced breast cancer. At ESMO Congress 2026, the randomized […]
AI Summary: FOURLIGHT‑1 reports that atirmociclib meaningfully lowered the risk of progression in patients with endocrine‑resistant metastatic breast cancer previously treated with CDK4/6 inhibitors, extending median progression‑free survival by roughly three months. The results provide a new treatment option for a refractory population, though the clinical impact must be weighed against tolerability and sequencing choices.
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